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Title   경계성 , 침윤성 및 전이성 난소암에서 나타나는 Class 1 및 Class 2 인간 주조직 적합성 항원들의 발현 이상 ( Alterations of HLA Class 1 and 2 Antigen Expressions in Borderline, Invasive and Metastatic Ovarian Cancers )
Publicationinfo   2000 Jan; 032(06): 1031-1043.
Key_word   Ovary neoplasm , HLA class 1 , HLA class 2
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Abstract   Purpose: The relationship between altered HLA expressions and ovarian carcinogenesis is not fully elucidated. Materials and Methods: Histological evaluation comprised 20 serous adenocarcinoma, 5 borderline serous malignancy, 10 mucinous adenocarcinoma, 15 borderline mucinous malignancy. We used monoclonal antibodys to HLA class I p2-microglobulin, class I B/C and class II heavy chain. Results: There was no statistical difference in HLA expressions between borderline serous malignancy and normal ovarian tissue. In serous adenocarcinoma, 02-microglobulin, B/C and class II heavy chain expressions were down-regulated. In metastatic cancer, B/C and class II expressions were also down-regulated. But the HLA expression of tumor or normal stromal tissue in primary tumor, were not down-regulated compared with the tissues in metastasis. In borderline mucinous malignancy, class II expressions were down-regulated. In mucinous adenocarcinoma, 2-microglobulin, B/C and class II expressions were down-regulated. In metastatic ovarian cancer, B/C and class II expressions were down-regulated. But, in borderline malignancy, the result failed to reach statistical significance except class II of borderline mucinous malignancy. Conclusion: Loss of HLA class I and II molecules in invasive ovarian cancers raises the possibility that this could be a mechanism for tumor cells to have invasiveness,
저 자   김진우(Jin Woo Kim),김윤경(Yun Kyong Kim),유영옥(Young Oak Lew),지성배(Sung Bae Jee),김규문(Gyu Moon Kim),최미영(Mi Young Choi),강미지(Mi Ji Kang),이용석(Yong Seok Lee)